Careers

1. Sequence design of siRNA drugs on the existing platform of Saint Germain.

2. Based on the existing data of the company, further optimize the siRNA drug design platform through machine learning and algorithm optimization, improve the rationality of sequence design and the reliability of off target prediction, etc.

3. Perform data analysis of RNAseq and single cell seq to provide bioinformatics support for in vitro and in vivo efficacy and safety evaluations, including off target analysis.

4. Collaborate with the team to conduct research on drug targets and optimize chemical modifications.

5. Assist in establishing and maintaining a database.

6.Assist in writing and reviewing application documents, articles, patents, etc.

1. Doctoral degree or master's degree with at least two years of work experience; Background in bioinformatics or other related fields.

2. Familiar with RNA biology and oligonucleotide technology, with experience in siRNA drug discovery is preferred, and work experience in targeting, drug design, or chemical modification is preferred.

3. Familiar with bioinformatics data resources and analysis tools, with RNA and DNA analysis skills and experience.

4. Proficient in at least one commonly used scripting language (such as R Python Perl), able to independently write analysis programs using scripting languages, and have good programming habits.

5. Strong subjective initiative and teamwork spirit.

6.Willing to learn new knowledge and skills.

1. Develop LC-MS and LC-MS/MS methods for quantitative analysis of oligonucleotides in blood and different tissues to support PK/PD studies of oligonucleotides.

2. Develop extraction methods for oligonucleotides in blood and different tissues to achieve efficient and stable oligonucleotide extraction.

3. Quantitative analysis, metabolic product analysis, and stability analysis of oligonucleotides in biological tissues to support ADME research.

4. Responsible for the preparation of daily biological analysis samples, LC-MS testing, and data analysis.

5. Responsible for promoting the progress and technology transfer of projects developed in CRO.

6. Write and optimize experimental standard operations for various parts of bioanalysis.

7. Develop LC-MS method for characterization and quantitative analysis of PD biomarkers in biological tissues.

8. Design and implement a series of in vitro experiments to study the stability of oligonucleotides, RISC binding ability, etc., to support platform research.

9. Assist in preparing and writing patent applications, literature, and project plans.

10. Actively cooperate with other departments to promote the progress of each project.

1. Bachelor's degree in Analytical Chemistry, Organic Chemistry, or Biochemistry or related fields, with at least 5 years of industrial work experience; Or a master's degree in a related field with at least two years of work experience in the industry; Or a PhD in a related field.

2. Have a deep understanding of analytical chemistry and a certain knowledge reserve in organic chemistry.

3. Ability to independently analyze and solve problems.

4. Able to independently and proficiently solve common problems with LC-MS, IPRP, and IEX. Having a clear understanding of relevant instruments and detection principles can solve the problem of related instrument malfunctions.

5. Proactively plan, arrange, promote project progress, and prioritize the importance of the project.

6. Excellent communication skills, English expression skills, and reporting skills.

7. Having excellent teamwork skills, able to play a role and grow in multidisciplinary teams.

1. Assist in the early development of small nucleic acid drugs.

2. Responsible for experiments related to cell, molecular biology, and immunity.

3. Assist in the construction of the analysis platform, including off target evaluation, etc.

1. Molecular biology, cell biology, molecular immunology, bioengineering, or other related majors in the field of biomedicine.

2. At least 2 years of undergraduate education and 1 year of biology related experience with a master's degree.

3. Proficient in cell culture, transfection, PCR, protein expression analysis (Western blot, Elisa) and other technologies, with experience in molecular biology or immunology experiments, or experience in small nucleic acid drug development is preferred.

4. Proficient in using various office software, responsible and proactive in work, with a strong sense of responsibility, good communication skills, and a good team spirit.

1. Operation of oligonucleotide synthesizers and downstream processing equipment.

2. Lab works on the oligonucleotide manufacture processes, including but not limited to synthesis, deprotection, purification, desalting and freeze-drying.

3. Work with supervisors on process optimization and scale-up of novel oligonucleotide platforms.

4. Follow all safety guidelines and requirements. Conduct laboratory work in a safe and efficient manner.

5. Follow standard operating procedures, good laboratory practice, and maintain accurate and complete lab documentation in accordance with company/department policies.

6. Data collection and summary to present to internal team.

1. B.S. in chemistry or similar majors, preferred with organic chemistry background.

2. Able to follow the operational procedures to work with pa.

3. Basic knowledge on the principles of analytical instruments, such as UV-vis, LC-MS, pH meter, conductivity meters, HPLC, etc.

4. Demonstrated basic communication abilities in English, such as reading and writing.

5. Lab experience and/or industrial experience is a plus, in particularly in oligonucleotide, nucleic acid chemistry, and/or bioconjugations.

6. Demonstrated ability to work collaboratively in a cross-functional/multi-disciplinary team.

7. Good planning and organization skills.